X-Message-Number: 11586
Date: Tue, 20 Apr 1999 23:25:42 -0700 (PDT)
From: Doug Skrecky <>
Subject: cysteine and heart preservation

Authors
  Holdefer MM.  Wicomb WN.  Levy JV.  Collins GM.
Institution
  California Pacific Medical Center Research Institute, San Francisco 94115.
Title
  Cardiotonic effects of reduced sulfhydryl amines after preservation of rabbit
  hearts.
Source
  Journal of Heart & Lung Transplantation.  13(1 Pt 1):157-9, 1994 Jan-Feb.
Abstract
  This investigation was designed to examine the role of glutathione and other
  reduced sulfhydryl amines during reperfusion of the ischemic rabbit heart. To
  identify the biochemical features of reduced sulfhydryl amines contributing
  toward improved myocardial function, we investigated several chemical agents
  sharing a common property with glutathione (L-leucine, L-glycine, ascorbate,
  oxidized glutathione, L-cysteine). After a period of 24-hour
  hypothermic storage of the rabbit heart in a modified University of Wisconsin
  solution containing polyethylene glycol, the hearts were functionally
  evaluated on a Langendorff working heart model. The agents were then injected
  as a bolus (60 mumol/L) during reperfusion, and coronary flow and aortic
  output were measured. Control hearts were untreated. Reduced sulfhydryl
  amines (glutathione, L-cysteine) significantly improved
  coronary flow (p < 0.005) and cardiac output (p < 0.005). Ascorbate,
  L-leucine, L-glycine, and oxidized glutathione all failed to influence
  cardiac function.

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