X-Message-Number: 12073
Date: Mon, 5 Jul 1999 18:59:40 -0700 (PDT)
From: Doug Skrecky <>
Subject: antioxidants in thyme

Authors
  Haraguchi H.  Saito T.  Ishikawa H.  Date H.  Kataoka S.  Tamura Y.  Mizutani
  K.
Institution
  Faculty of Engineering, Fukuyama University, Japan.
Title
  Antiperoxidative components in Thymus
  vulgaris.
Source
  Planta Medica.  62(3):217-21, 1996 Jun.
Abstract
  A biphenyl compound,
  3,4,3',4'-tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (1), and a
  flavonoid, eriodicytol (2), were isolated as antioxidative
  components from the leaves of Thymus vulgaris by
  bioassay-directed fractionation. These compounds inhibited superoxide anion
  production in the xanthine/xanthine oxidase system. Mitochondrial and
  microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or
  Fe(III)-ADP/NADPH were also inhibited by these compounds. Compound 1 is an
  extremely potent antioxidant; complete inhibition was observed at 1 microM
  against both microsomal and mitochondrial peroxidation. Furthermore, compound
  1 protected red cells against oxidative hemolysis. These phenolic compounds
  were shown to be effective to protect biological systems against various
  oxidative stresses.

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