X-Message-Number: 12520
Date: Thu, 7 Oct 1999 20:55:08 -0700 (PDT)
From: Doug Skrecky <>
Subject: diethylene glycol monomethyl ether is relatively nontoxic

Authors
  Hobson DW.  D'Addario AP.  Bruner RH.  Uddin DE.
Title
  A subchronic dermal
  exposure study of diethylene glycol
  monomethyl ether and ethylene glycol monomethyl ether in the male guinea pig.
Source
  Fundamental & Applied Toxicology.  6(2):339-48, 1986 Feb.
Abstract
  Diethylene glycol monomethyl ether (DEGME) has been selected as a replacement
  anti-icing additive for ethylene glycol monomethyl ether (EGME) in Navy jet
  aircraft fuel. This experiment was performed to determine whether DEGME
  produced similar toxicity to EGME following dermal
  exposure. Male guinea pigs were dermally
  exposed to 1.00, 0.20, 0.04, or 0 (control) g/kg/day DEGME for 13 weeks, 5
  days/week, 6 hr/day. Another group of animals was similarly exposed to 1.00
  g/kg/day EGME. Body weights as well as testicular and splenic weights were
  reduced as a result of exposure to EGME, DEGME-exposed
  animals exhibited decreased splenic weight in the high- and medium-dose (1.00
  and 0.20 g/kg/day) exposure groups only. Hematologic changes
  in EGME-exposed animals included mild anemia with increased erythrocytic mean
  corpuscular volumes and a lymphopenia with increased neutrophils. Similar
  hematological changes were not observed in any animals exposed to DEGME.
  Serum creatine kinase activity was increased in animals exposed to EGME, and
  serum lactate dehydrogenase activity was increased in EGME and 1.00 g/kg/day
  DEGME-exposed animals. In general, DEGME produced minimal toxicological
  changes following dermal exposure, whereas
  the toxicological changes observed following similar
  exposure to EGME were much more profound.

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