X-Message-Number: 12531
Date: Sat, 9 Oct 1999 12:46:42 -0700 (PDT)
From: Doug Skrecky <>
Subject: little toxicity with diethylene glycol monoethyl ether

Authors
  Hardin BD.  Goad PT.  Burg JR.
Title
  Developmental toxicity of
  four glycol ethers applied cutaneously to rats.
Source
  Environmental Health Perspectives.  57:69-74, 1984 Aug.
Abstract
  Previous NIOSH studies demonstrated the embryo- and
  fetotoxicity and teratogenicity of ethylene glycol monoethyl
  ether (EGEE) applied to the shaved skin of pregnant rats. In the present
  study ethylene glycol monoethyl ether acetate (EGEEA), ethylene glycol
  monobutyl ether (EGBE), and diethylene glycol monoethyl ether (diEGEE) were
  tested in the same experimental model, using distilled water as the negative
  control and EGEE as a positive control. Water or undiluted glycols were
  applied four times daily on days 7 to 16 of gestation to the
  shaved interscapular skin with an automatic pipetter. Volumes of EGEE (0.25
  mL), EGEEA (0.35 mL), and diEGEE (0.35 mL) were approximately equimolar (2.6
  mmole per treatment). EGBE at 0.35 mL four times daily
  (approximately 2.7 mmole per treatment) killed 10 of 11 treated rats, and was
  subsequently tested at 0.12 mL (0.9 mmole) per treatment. EGEE- and
  EGEEA-treated rats showed a reduction in body weight relative to water
  controls that was associated with completely resorbed litters and
  significantly fewer live fetuses per litter. Fetal body weights were also
  significantly reduced in those groups. Visceral malformations and skeletal
  variations were significantly increased in EGEE and EGEEA groups over the
  negative control group. No embryotoxic, fetotoxic, or teratogenic effects
  were detected in the EGBE- or diEGEE-treated litters.

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