X-Message-Number: 12919 From: Thomas Donaldson <> Subject: ASCII form of notice to be sent out to owners of the GUIDE Date: Thu, 9 Dec 1999 23:28:25 +1100 (EST) Hi everyone! Here is the text form of the message I will be sending out about the new Updates. If you are interested, please contact me by email and you can not only get your Updates sooner, but save the cost of sending you this notice by ordinary mail (airmail, actually) from Australia. New Updates for A Guide to AntiAging Drugs There are four new Updates available: 1. A new chapter, Chapter 15, on Ginkgo biloba Not long ago one author, JC Winter, in experimenting with a standard Ginkgo biloba extract given to rats, also tested their longevity. It turned out that they lived significantly longer. The reason for this may come from the simple fact that some of the chemicals in the extract are antioxidants, but its other effects suggest that there may be more than that. This chapter describes Winter's experiment and also other work on the same extract for other conditions, too. For instance, it may also help Alzheimer's patients. It also describes the one known toxic effect of the extract, and discusses possible doses for antiaging. Price of Chapter 15: US $10. 2. Additions to Appendix 2, Drugs Waiting in the Wings. The first addition is the antioxidant PBN, which has shown good results with animals but so far lacks any test on human beings. As with other drugs that did not qualify for an Chapter, the discussion gives references so that you can read up on this chemical yourselves. Price of change of Appendix 2: US 1.00 3. Addition to Chapter 8, Deprenyl, A New Drug against Aging. Another series of experiments with deprenyl gave no increase in lifespan. I personally suspect this happened simply because the authors used too little deprenyl, but readers should decide this for themselves. The addition to this chapter came at the beginning, which meant that the price is more than $1.00 because the discussion that came afterwards had to move. Price of change to Chapter 8: US $2.00 4. Addition to Chapter 14, Human Growth Hormone, Outgrowing Aging Describes some recent negative experiments on the effect of HGH on lifespan, with discussion of their merit as experiments. The authors of these new experiments tried to duplicate the work of Khansari and Gustad exactly, but actually do not do so. Some of their results come close to suggesting that HGH will increase lifespan in their rats or mice, but the effect they got wasn't strong enough for statistical significance. As with Chapter 8, the discussion of this experiment occurs early in Chapter 14 and therefore moves everything else. This accounts for its slightly larger price. Price of change to Chapter 14: US $2.00. All changes are modifications to the previous text. If you want your Updates not as modified chapters but as separate Update Notes to be added after each Chapter, please enquire. This form remains available but only if specifically requested. Such additions to Chapters 8 and 14 are each US $1.00. PRICE OF ALL UPDATES TOGETHER: US $15.00 plus POSTAGE FROM AUSTRALIA: For airmail postage to the US, US $4.30; to Europe, US $4.30; to NZ, US $3.00; to Australia, US $1.60; for elsewhere, please enquire. Checks are acceptable as payments, but credit cards are not. Please make out all checks to ME, Thomas Donaldson. Please send any request for these new Updates to: PERIASTRON Publishing PO Box 208 O'Connor ACT 2602 AUSTRALIA Email: Telephone: 612- 6257-4411 Ideally, sending the request by email would be best; note my email address. Best wishes and long long life to all, Thomas Donaldson Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=12919