X-Message-Number: 13061 Date: Wed, 5 Jan 2000 10:32:18 -0800 (PST) From: Doug Skrecky <> Subject: could luteolin be useful in organ transplantation? Authors Rump AF. Schussler M. Acar D. Cordes A. Theisohn M. Rosen R. Klaus W. Fricke U. Institution Institut fur Pharmakologie, Universitat Koln, Germany. Title Functional and antiischemic effects of luteolin-7-glucoside in isolated rabbit hearts. Source General Pharmacology. 25(6):1137-42, 1994 Oct. Abstract 1. The functional effects of the flavonoid luteolin-7-glucoside (LUT) were investigated in Langendorff-rabbit hearts perfused at constant pressure. Repetitive myocardial ischemia was induced by coronary artery ligature and quantified from NADH-fluorescence photography. 2. LUT significantly enhanced left ventricular pressure and the global and relative coronary flow (= global coronary flow/pressure-rate product). 3. LUT significantly diminished epicardial NADH-fluorescence area and intensity. 4. LUT is an inodilator possessing cardioprotective properties. These might be related to an improvement of myocardial perfusion and/or to free radical scavenging properties. Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=13061