X-Message-Number: 13384 Date: Sun, 12 Mar 2000 20:18:25 -0800 (PST) From: Doug Skrecky <> Subject: pathogens may induce senescence in podospora anserina Citations: 1-3 <1> Authors Jamet-Vierny C. Rossignol M. Haedens V. Silar P. Institution Institut de Genetique et Microbiologie, URA 2225, Universite de Paris Sud, Orsay cedex, 91405, France. Title What triggers senescence in Podospora anserina?. Source Fungal Genetics & Biology. 27(1):26-35, 1999 Jun. Abstract Senescence of Podospora anserina is triggered by a cytoplasmic and infectious factor (the determinant of senescence) and is always correlated with mitochondrial DNA modifications, especially with the accumulation of small circular subgenomic DNA molecules, the senDNAs. Several observations have suggested that the senDNAs could be the cytoplasmic and infectious determinant. However, we show here (1) that senDNA molecules can be transferred to a young culture without the cotransmission of the determinant of senescence and (2) that the determinant of senescence does not segregate as a mitochondrial DNA mutation. Overall, our data strongly argue that amplification of senDNA molecules in the mitochondria is not an intrinsic property of these small DNA molecules. They question the nature of the actual determinant of senescence. Copyright 1999 Academic Press. <2> Authors Esser K. Tudzynski P. Title Prevention of senescence in the ascomycete Podospora anserina by the antibiotic tiamulin. Source Nature. 265(5593):454-6, 1977 Feb 3. <3> Authors Esser K. Keller W. Title Genes inhibiting senescence in the ascomycete Podospora anserina. Source Molecular & General Genetics. 144(1):107-10, 1976 Feb 27. Abstract Senescence occurs in all wild strains of Podospora anserina after continued growth. This syndrome can be inhibited by a synergistic interaction of two linked genes, incoloris and vivax. Whereas the wild strain starts to become senescent after 26 d and the mutants incoloris and vivax after 42 and 66 d respectively, the double mutant shows no signs of aging after culture for more than one year. Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=13384