X-Message-Number: 17175
Date: Thu, 02 Aug 2001 11:45:21 +0200
From: Henri Kluytmans <>
Subject: Nano repair of cryo-damage

Yvan Bozzonetti wrote :

>When most nano supporter think about nano repair, I feel they think in fact 
>about micro surgery done by micrometer sized robots. That technology may 
>indeed be produced as a spin off from micro electronics device making. It 
> would be useful in cryonics to repair cracks in frozen bodies for example.
>That would be fine, but it fall short of the requested capabilities to get 
>out of the frost. The main problems are at molecular level, we must reshape 
>badly folded proteins or membrane molecules. 

Nope, this is not required !

Badly folded proteins will reshape themselves as soon as the temperature 
returns to normal again. 

What needs to be repaired are broken proteines. The shape is not 
relevant, because when the temperature goes up again they will 
automatically regain the correct shape.

What needs to be repaired are :

- broken molecules
- shape of the cells (especially the neurons) 
- broken membrames
- macroscopic fractures
- removal of ice crystals
- restore extra-cellular and intra-cellular solute concentrations to normal
- repair of multi-molecular machinery (mitochondria, etc..)

For an extensive description of nano repair of cryo-damage see :

http://www.merkle.com/merkleDir/techFeas.html


>The problem: even the biggest supercomputer today can't solve that 
>problem of a single molecule.
 
Predicting how a proteine folds is not required for the repair job. 

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