X-Message-Number: 17228 From: "Jan Coetzee" <> Subject: brain ischaemia Date: Wed, 8 Aug 2001 22:08:47 -0400 This is a multi-part message in MIME format. ------=_NextPart_000_0017_01C12056.B2324600 Content-Type: multipart/alternative; boundary="----=_NextPart_001_0018_01C12056.B2324600" ------=_NextPart_001_0018_01C12056.B2324600 Content-Type: text/plain; charset="iso-8859-1" EPO signalling: Protection from brain ischaemia The hormone erythropoietin (EPO) regulates red blood cell production, and is used medically to treat anaemia, chronic kidney failure or drug toxicity. EPO is generally thought of as a kidney hormone, but is also produced in the brain following injury or stress. A clue as to the role of EPO in the brain comes with the finding that it protects primary cerebrocortical neurons from nitric oxide-induced cell death, acting via the Jak2 and NF-?B signalling cascades. This suggests that another therapeutic application might be possible for EPO or its derivatives, protecting the brain from damage by hypoxia or ischaemia. 9 August 2001 ------=_NextPart_001_0018_01C12056.B2324600 Content-Type: text/html; [ AUTOMATICALLY SKIPPING HTML ENCODING! ] Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=17228