X-Message-Number: 17228
From: "Jan Coetzee" <>
Subject: brain ischaemia
Date: Wed, 8 Aug 2001 22:08:47 -0400

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EPO signalling: Protection from brain ischaemia

The hormone erythropoietin (EPO) regulates red blood cell production, and is 
used medically to treat anaemia, chronic kidney failure or drug toxicity. EPO is
generally thought of as a kidney hormone, but is also produced in the brain 
following injury or stress. A clue as to the role of EPO in the brain comes with
the finding that it protects primary cerebrocortical neurons from nitric 
oxide-induced cell death, acting via the Jak2 and NF-?B signalling cascades. 
This suggests that another therapeutic application might be possible for EPO or 
its derivatives, protecting the brain from damage by hypoxia or ischaemia. 

9 August 2001




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