X-Message-Number: 17306 From: Date: Fri, 17 Aug 2001 22:39:30 EDT Subject: EUK-134 and cryonics --part1_29.19690cf6.28af2f62_boundary Content-Type: text/plain; charset="US-ASCII" Content-Transfer-Encoding: 7bit More from a Eukarion patent: ..."The compounds of the invention, antioxidant salen-transition metal complexes, preferably salen-Mn complexes, are useful treatments for protection against ischemic damage in cardiac and non-cardiac states including myocardial infarction, congestive heart failure, angina, arrhythmia, circulatory disorders, and stroke. The compounds of the invention inhibit the deleterious effects of ischaemia (coronary infarction and reperfusion in the heart; transient myocardial or CNS ischemia during surgery) without direct depressant effects on myocardial contractility. Thus, the compounds are effective in animal models for cardiovascular and CNS diseases, and will be useful for the treatment of myocardial infarction, stroke, brain injury, and transplant surgery, particularly with reperfusion of infarcted areas, arrhythmias, variant and exercise-induced angina, congestive heart failure, stroke and other circulatory disorders, in mammals, particularly in human beings. The salen-Mn complexes are also included in preservation solutions used to bathe excised organs (e.g., heart, kidney, pancreas, liver, lung) during transport and storage of the excised organ prior to transplantion surgery, including skin grafting and corneal grafting. The preservation solutions will typically comprise at least about 1 .mu.M of an antioxidant salen-metal complex, preferably at least about 1 mM of an antioxidant salen-metal complex. " It would seem that these compounds might be useful for protecting against free radical damage to reviving cryonics patients... of course since we don't know what the revival protocols ARE, we can't say for sure. Doesn't seem like they would hurt though. -Bill --part1_29.19690cf6.28af2f62_boundary Content-Type: text/html; charset="US-ASCII" [ AUTOMATICALLY SKIPPING HTML ENCODING! ] Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=17306