X-Message-Number: 17306
From: 
Date: Fri, 17 Aug 2001 22:39:30 EDT
Subject: EUK-134 and cryonics

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  More from a Eukarion patent:

..."The compounds of the invention, antioxidant salen-transition metal 
complexes, preferably salen-Mn complexes, are useful treatments for 
protection against ischemic damage in cardiac and non-cardiac states 
including myocardial infarction, congestive heart failure, angina, 
arrhythmia, circulatory disorders, and stroke. The compounds of the invention 
inhibit the deleterious effects of ischaemia (coronary infarction and 
reperfusion in the heart; transient myocardial or CNS ischemia during 
surgery) without direct depressant effects on myocardial contractility. Thus, 
the compounds are effective in animal models for cardiovascular and CNS 
diseases, and will be useful for the treatment of myocardial infarction, 
stroke, brain injury, and transplant surgery, particularly with reperfusion 
of infarcted areas, arrhythmias, variant and exercise-induced angina, 
congestive heart failure, stroke and other circulatory disorders, in mammals, 
particularly in human beings. The salen-Mn complexes are also included in 
preservation solutions used to bathe excised organs (e.g., heart, kidney, 
pancreas, liver, lung) during transport and storage of the excised organ 
prior to transplantion surgery, including skin grafting and corneal grafting. 
The preservation solutions will typically comprise at least about 1 .mu.M of 
an antioxidant salen-metal complex, preferably at least about 1 mM of an 
antioxidant salen-metal complex. "

   It would seem that these compounds might be useful for protecting against 
free radical damage to reviving cryonics patients... of course since we don't 
know what the revival protocols ARE, we can't say for sure. Doesn't seem like 
they would hurt though. -Bill



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