X-Message-Number: 17429 Date: Fri, 31 Aug 2001 05:14:21 -0700 (PDT) From: Doug Skrecky <> Subject: 4-methylpyrazole blocks ethylene glycol toxicity Title Ethylene glycol poisoning in a child treated with 4-methylpyrazole. Source Pediatrics. 102(3):E31, 1998 Sep. Abstract OBJECTIVE: The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. The purpose of the present case report was to demonstrate 4-MP efficiency in EG poisoning in a 4-year-old child. METHOD AND RESULTS: 4-MP Treatment was performed 7 hours after EG ingestion. Plasma EG and 4-MP concentrations were measured 2 hours after each infusion of 4-MP. Plasma 4-MP concentrations were in the range of the values reported to block EG metabolism. The efficiency of 4-MP treatment was confirmed by the rapid correction of metabolic acidosis without alkalization and by the increase in EG half-life. No adverse effect of 4-MP was observed. CONCLUSION: This child ingested a potentially lethal dose of EG despite a high concentration of bittering agent in antifreeze. EG poisoning was treated efficiently by 4-MP without recourse to hemodialysis. Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=17429