X-Message-Number: 17429
Date: Fri, 31 Aug 2001 05:14:21 -0700 (PDT)
From: Doug Skrecky <>
Subject: 4-methylpyrazole blocks ethylene glycol toxicity

Title
  Ethylene glycol poisoning in a child
  treated with 4-methylpyrazole.
Source
  Pediatrics.  102(3):E31, 1998 Sep.
Abstract
  OBJECTIVE: The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a
  new antidote of ethylene glycol (EG)
  intoxication. The purpose of the present case report was to demonstrate 4-MP
  efficiency in EG poisoning in a 4-year-old child. METHOD AND RESULTS: 4-MP
  Treatment was performed 7 hours after EG ingestion. Plasma EG and 4-MP
  concentrations were measured 2 hours after each infusion of 4-MP. Plasma 4-MP
  concentrations were in the range of the values reported to block EG
  metabolism. The efficiency of 4-MP treatment was confirmed by the rapid
  correction of metabolic acidosis without alkalization and by the increase in
  EG half-life. No adverse effect of 4-MP was observed. CONCLUSION: This child
  ingested a potentially lethal dose of EG despite a high concentration of
  bittering agent in antifreeze. EG poisoning was treated efficiently by 4-MP
  without recourse to hemodialysis.

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