X-Message-Number: 18970 From: Date: Thu, 25 Apr 2002 21:02:55 EDT Subject: antioxidants in perfusates (Brent) --part1_12e.1072659b.29fa013f_boundary Content-Type: text/plain; charset="US-ASCII" Content-Transfer-Encoding: 7bit >basically the interesting part of it is in transplanted livers damaged by alcohol (and isnt alcohol in many ways similar to the preserving components of perfusates?) the use of green tea extracts (epigallocatechin gallate) blunted graft trauma. They suspect this was due largely to its scavenging ability against free radicals caused by the trauma. >This got me thinking that in a cryonics attempt (perfuse, freeze, rewarm) there is probably a lot of cellular level trauma and I wondered what if any attempts had been made to measure the effects of free radical scavengers added to a perfusate in terms The Eukarion company has developed a series of small-molecule SOD/catalase mimics (e.g. EUK-8, EUK-134) which have been shown to increase C. Elegans lifespan 44%. They are testing them for use as anti-trauma agents for surgery. I think something like this should be added to perfusates as long as it doesn't interfere with ice crystal blocking. -Bill --part1_12e.1072659b.29fa013f_boundary Content-Type: text/html; charset="US-ASCII" [ AUTOMATICALLY SKIPPING HTML ENCODING! ] Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=18970