X-Message-Number: 18970
From: 
Date: Thu, 25 Apr 2002 21:02:55 EDT
Subject: antioxidants in perfusates (Brent)

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>basically the interesting part of it is in transplanted livers damaged by 
alcohol (and isnt alcohol in many ways similar to the preserving components 
of perfusates?) the use of green tea extracts (epigallocatechin gallate) 
blunted graft trauma. They suspect this was due largely to its scavenging 
ability against free radicals caused by the trauma.

>This got me thinking that in a cryonics attempt (perfuse, freeze, rewarm) 
there is probably a lot of cellular level trauma and I wondered what if any 
attempts had been made to measure the effects of free radical scavengers 
added to a perfusate in terms

  The Eukarion company has developed a series of small-molecule SOD/catalase 
mimics (e.g. EUK-8, EUK-134) which have been shown to increase C. Elegans 
lifespan 44%. They are testing them for use as anti-trauma agents for 
surgery. I think something like this should be added to perfusates as long as 
it doesn't interfere with ice crystal blocking. -Bill


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