X-Message-Number: 19534 From: "brent thomas" <> Subject: [Research: neuron death factors and inhibitors] - cryoprotectent additives? Date: Tue, 16 Jul 2002 19:09:37 -0400 This is a multi-part message in MIME format. ------=_NextPart_000_0067_01C22CFC.53EAC230 Content-Type: text/plain; charset="iso-8859-1" I think the coming convergence of biotechnology and nanotechnology will bring about an increased understanding of the physical processes which cells undergo especially as it relates to stressful events. an interesting article here http://www.eurekalert.org/pub_releases/2002-07/jhmi-ncd071602.php discusses neuronal cell death processes and shows evidence that the process is tied (at least in part) to the mechanics of an enzyme called PARP and subsequent production of AIF due to PARP release. Since cryonics is an event which is (to put it mildly) traumatic to all cells (neurons included) and we've got a special interest in preserving nerve function then it would be to our advantage to look into process mechanics such as this and investigate what types of 'additives' can be introduced to cryprotectant solutions which will serve not as a cryo protectant but instead as a cell protectant (structure, integrity, operation, mechanics etc). some form of PARP antagonist which would sequester trauma induced PARP and prevent AIF production would be an excellent start... ...we might as well investigate things like this because they will probably 'make it easier' on the reconstructor nano-bots 'on the other side' if they have a minimum of cell trauma to deal with... ... it is even possible that many 'additives' of this sort could be administered pre-mortem (for those of us lucky enough to have a reasonable certainty of upcoming de-animation) in a kind of loading process which would raise concentrations of useful additives throughout the body prior to de-animation and primary cryo-protectant administration... ------=_NextPart_000_0067_01C22CFC.53EAC230 Content-Type: text/html; [ AUTOMATICALLY SKIPPING HTML ENCODING! ] Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=19534