X-Message-Number: 19597
Date: Tue, 23 Jul 2002 13:09:55 -0700 (PDT)
From: Scott Badger <>
Subject: CR mimetics

It may be old news to some, but I hadn't heard about
this work. You get the beneficial life extending
effects of caloric restriction ... without starving.

Here's a current Scientific American article
discussing it.



http://www.sciam.com/article.cfm?articleID=000BC08E-5B8C-1D2B-97CA809EC588EEDF&catID=2

Also, here's an abstract that suggests anti-diabetics
such as metformin may be effective CR mimetics.

http://www.americanaging.org/abs/Roth.htm

An enthusiastic article on metformin by Ward Dean, MD

http://www.smart-drugs.com/Ward-Dean-metformin.htm

Interesting. Decreased sensitivity to insulin is so
common among older adults that almost all in their 40s
or over are considered barely sub-clinical for
diabetes.

Note to those who consider taking metformin, consider
supplementing with generous doses of B-12 and monitor
your insulin level to avoid hypoglycemia.

Does anyone have useful experience or knowledge in
this area?

Scott Badger

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