X-Message-Number: 20251
From: "Basie" <>
Subject: molecules flow through solid tissue
Date: Thu, 3 Oct 2002 21:41:33 -0400

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Co-author Edward H. Oldfield, M.D., chief of the Surgical Neurology Branch at 
NINDS, and colleagues developed CED in 1994. The technique uses small 
differences in pressure to make infused molecules flow through solid tissue. 
This enables large molecular weight molecules, such as those used in drugs, to 
penetrate the brainstem. Researchers have refined and expanded the uses of CED 
during the past 8 years, but until now, there has been no way to track precisely
where the drugs were going and therefore no way to predict or prevent adverse 
side effects. 

The study appears in the October 2002 issue of the Journal of Neurosurgery. 

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