X-Message-Number: 20849 From: Date: Mon, 13 Jan 2003 06:24:21 EST Subject: Re: CryoNet #20816 Perfusate --part1_1bc.1b14524a.2b53fbe5_boundary Content-Type: text/plain; charset="US-ASCII" Content-Transfer-Encoding: 7bit > This is simply not the case. The work of Fahy et al with rabbit kidneys is > still not 100% successful, after many years of work, but it is very close, > since according to reports they have gotten around 50% viability > clinically--half the specimens allowed long term survival of rabbits using > previously vitrified kidneys. 50% isn't good enough for organ transplants, > but it's certainly good enough for proof of principle. > > Kidney is not the most sensible organ, but assume it is in the average. Assume there are 20 essential organs or systems in the body, if each has a faillure probability of 50%, then the survival probability is one in one million. That give a mesure of the road to come. To be sure, an organ in a body is harder to wash out than one taken outside. Non essential parts of the body would too discharge some cryoprotectant in the general blood flow, reducing the washout efficiency in sensible area. In the brain, global survival is not sufficient, even 99% survival would let very heavy scare. Most profound neurological disorders have their roots in brain defects far smaller. With 1% neurological destruction, prepare for a survival in a state of ultimate psychosis. Well, in some case larger destructions can be overcome, but they are limited to a (non essential) well defined area. Here, the destruction would affect all neural centers more or less in the same way. May be wash out will discard 90% of the toxic product, What remain will have to be destroyed in situ one way or another. Given that the biological environment forbids nonselective methods such thermal, agressive chemical or ionising radiations, the only issue is with light excitation. To deliver it in an opaque medium, it must be produced in situ. Doing that without ionisation let no other possibility than thousands of optical fibers or no rest frame fields. Yvan Bozzonetti. --part1_1bc.1b14524a.2b53fbe5_boundary Content-Type: text/html; charset="US-ASCII" [ AUTOMATICALLY SKIPPING HTML ENCODING! ] Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=20849