X-Message-Number: 20849
From: 
Date: Mon, 13 Jan 2003 06:24:21 EST
Subject: Re: CryoNet #20816 Perfusate

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> This is simply not the case. The work of Fahy et al with rabbit kidneys is 
> still not 100% successful, after many years of work, but it is very close, 
> since according to reports they have gotten around 50% viability 
> clinically--half the specimens allowed long term survival of rabbits using 
> previously vitrified kidneys. 50% isn't good enough for organ transplants, 
> but it's certainly good enough for proof of principle.
> 
> 

Kidney is not the most sensible organ, but assume it is in the average. 
Assume there are 20 essential organs or systems in the body, if each has a 
faillure probability of 50%, then the survival probability is one in one 
million. That give a mesure of the road to come. To be sure, an organ in a 
body is harder to wash out than one taken outside. Non essential parts of the 
body would too discharge some cryoprotectant in the general blood flow, 
reducing the washout efficiency in sensible area.

In the brain, global survival is not sufficient, even 99% survival would let 
very heavy scare. Most profound neurological disorders have their roots in 
brain defects far smaller. With 1% neurological destruction, prepare for a 
survival in a state of ultimate psychosis. Well, in some case larger 
destructions can be overcome, but they are limited to a (non essential) well 
defined area. Here, the destruction would affect all neural centers more or 
less in the same way.

May be wash out will discard 90% of the toxic product, What remain will have 
to be destroyed in situ one way or another. Given that the biological 
environment forbids nonselective methods such thermal, agressive chemical or 
ionising radiations, the only issue is with light excitation. To deliver it 
in an opaque medium, it must be produced in situ. Doing that without 
ionisation let no other possibility than thousands of optical fibers or no 
rest frame fields.

Yvan Bozzonetti.



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