X-Message-Number: 20983
From: 
Date: Mon, 27 Jan 2003 08:40:09 EST
Subject: Protein denaturation

--part1_1e3.68e74c.2b6690b9_boundary
Content-Type: text/plain; charset="US-ASCII"
Content-Transfer-Encoding: 7bit


Proteins are not simply defined by a chemical formula, what make them work is 
the special folding they take. That rests on their polar interaction with 
water molecules. If something, such drying, too much heat, noxious chemicals 
unfold to some extent a protein, there is few chance it will fold again in 
the proper way. The protein get denaturated. Denaturation can be a catalytic 
process: some misfolding can interact with properly folded molecules and turn 
them in bad form identical to them, this what we call prions.

All cells have a built in defense against that process, it is called heat 
shock protein complex (HSP). These HSP take a badly folded molecule and act 
as a mold to cast it in the proper shape.  That process consume some energy 
in the form of adenosine tri-phosphate. When a cell is too much stressed, for 
example by drying, its energy producing system is out of order and there is 
no power to repair the cell. The HSP complex itself can be denaturated and 
being unable to fulfil its task.

Some plants have a particularly strong set of HSP systems. If we had the 
same, we would live 300 to 500 years. My idea is to fix such complexes on a 
clay crystal, working as a stabilizer. On that support, the HSP would resist 
strongly to any denaturation. The clay crystal can include a radio receiver 
producing some electric power at the rectifier output. These free electrons 
would feed a mitochondrial-like energy converter so that the end product 
would be ATP able to power the HSP. The clay surface stabilizing effect would 
permit harsh environment work, such freezing.

The HSP complexes can be extracted from plants by centrifugation, the 
mitochondrial energy converter can be recovered in the same way. A clay 
crystal can be folded as said in another message, so that given molecules 
plug in at prescribed sites. Why not try that?

Potential uses: Cryonics repair, life extension, burn healing, prions 
neutralization,...

Yvan Bozzonetti.

--part1_1e3.68e74c.2b6690b9_boundary

 Content-Type: text/html; charset="US-ASCII"

[ AUTOMATICALLY SKIPPING HTML ENCODING! ] 

Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=20983