X-Message-Number: 20983 From: Date: Mon, 27 Jan 2003 08:40:09 EST Subject: Protein denaturation --part1_1e3.68e74c.2b6690b9_boundary Content-Type: text/plain; charset="US-ASCII" Content-Transfer-Encoding: 7bit Proteins are not simply defined by a chemical formula, what make them work is the special folding they take. That rests on their polar interaction with water molecules. If something, such drying, too much heat, noxious chemicals unfold to some extent a protein, there is few chance it will fold again in the proper way. The protein get denaturated. Denaturation can be a catalytic process: some misfolding can interact with properly folded molecules and turn them in bad form identical to them, this what we call prions. All cells have a built in defense against that process, it is called heat shock protein complex (HSP). These HSP take a badly folded molecule and act as a mold to cast it in the proper shape. That process consume some energy in the form of adenosine tri-phosphate. When a cell is too much stressed, for example by drying, its energy producing system is out of order and there is no power to repair the cell. The HSP complex itself can be denaturated and being unable to fulfil its task. Some plants have a particularly strong set of HSP systems. If we had the same, we would live 300 to 500 years. My idea is to fix such complexes on a clay crystal, working as a stabilizer. On that support, the HSP would resist strongly to any denaturation. The clay crystal can include a radio receiver producing some electric power at the rectifier output. These free electrons would feed a mitochondrial-like energy converter so that the end product would be ATP able to power the HSP. The clay surface stabilizing effect would permit harsh environment work, such freezing. The HSP complexes can be extracted from plants by centrifugation, the mitochondrial energy converter can be recovered in the same way. A clay crystal can be folded as said in another message, so that given molecules plug in at prescribed sites. Why not try that? Potential uses: Cryonics repair, life extension, burn healing, prions neutralization,... Yvan Bozzonetti. --part1_1e3.68e74c.2b6690b9_boundary Content-Type: text/html; charset="US-ASCII" [ AUTOMATICALLY SKIPPING HTML ENCODING! ] Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=20983