X-Message-Number: 22234
Date: Sun, 20 Jul 2003 20:14:16 -0700 (PDT)
From: Doug Skrecky <>
Subject: blueberries versus alzheimer's

Nutr Neurosci. 2003 Jun;6(3):153-62.
	Blueberry supplementation enhances signaling and prevents
behavioral deficits in an Alzheimer disease model.
	Previously, we showed that blueberry (BB) supplementation
reversed the deleterious effects of aging on motor behavior and neuronal
signaling in senescent rodents. We now report that BB-fed (from 4 months
of age) APP + PS1 transgenic mice showed no deficits in Y-maze
performance (at 12 months of age) with no alterations in amyloid beta
burden. It appeared that the protective mechanisms are derived from
BB-induced enhancement of memory-associated neuronal signaling (e.g.
extracellular signal-regulated kinase) and alterations in neutral
sphingomyelin-specific phospholipase C activity.
	Thus, our data indicate for the first time that it may be
possible to overcome genetic predispositions to Alzheimer disease through
diet.

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