X-Message-Number: 22444 Date: Sun, 31 Aug 2003 12:26:02 -0700 (PDT) From: Doug Skrecky <> Subject: NAD & Sir In Message #22441 "michaelprice" <> wrote: > NAD (the coenzyme form of vitamin B3) is a > substrate for sirtuins, which consequently up-regulates sirtuin > activity. > I'm told it does not. NAD is not a limiting factor for Silent Information Regulator activity under normal circumstances. Nicotinamide can reduce SIR activity by blocking the NAD site, but niacin has no effect. Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=22444