X-Message-Number: 22448
From: "Igor Artyuhov" <>
References: <>
Subject: Re: four-amino-acid peptide telomerase activator [WalkerBill] #22437
Date: Mon, 1 Sep 2003 13:28:01 +0400

Epithalon is a synthetic analog of a peptide Epithalamin. It is a
tetrapeptide including alanine, glutamine, glycine, and aspartic acid.
Epithalamin is one of the Cytamines - signaling peptides extracted from the
mammal's glands by Khavinson and his group in St. Petersburg Institute of
Bioregulation and Gerontology. At least two of them (Epithalamin and Vilone)
have been shown to increase medium longevity in several species of animals.
Biological activity of epithalone is believed to be higher than that of

There are many resources on them in Russian; those in English I know are:
- http://www.gerontology.ru/posters3.html
- http://www.vrp.com/articles/519.asp

From "The Neuroendocrine Theory of Aging: Chapter Seven, Part II
Restoring Receptor Sensitivity: A Key to AntiAging" by Ward Dean, MD

Melatonin's 'relatives,' EpithalaminT and EpithalonT
EpithalaminT is a melatonin-free, pineal polypeptide fraction that is
classified as a drug in Russia. Dilman and other scientists in Russia
demonstrated extension of lifespan in rats that were treated with
Epithalamin.(14) Professor Vladimir Anisimov, who worked in Dilman's
laboratory from 1973-1979, later replicated these results in fruitflies,
mice and rats.(15) Epithalamin extended the mean survival of rats by 5.3%,
and the maximum lifespan by 10 months (Fig. 8).
The active polypeptide in Epithalamin is a combination of the amino acids
alanine, glutamine, glycine, and aspartic acid. This synthetic pineal
extract has been identified and synthesized. Called EpithalonT this
substance is now being developed as a drug in Russia. The scientists also
stated that Epithalon 'slows down aging of reproductive function, inhibits
free radical processes, and reduces the incidence of tumors.'
Dilman believed that the principle mechanism and benefit of Epithalamin was
to restore hypothalamic sensitivity to more youthful levels. Prof. Vladimir
Khavinson,(16) principal scientist, author and owner of the patent for
Epithalon, agrees that the major mechanism of Epithalon is its interaction
with specific receptors. Khavinson and his associates found that effective
doses of Epithalon were 16,000 to 80,000,000 times lower than those of
melatonin (in fact, one of Epithalon's effects is to stimulate release of
melatonin). Khavinson calculated that an effective dose for humans would be
in the range of 0.075 microgram per day (0.991 microgram/kg bodyweight).

Original message:

Message #22437
Date: Sat, 30 Aug 2003 10:25:35 EDT
Subject: four-amino-acid peptide telomerase activator

There's an abstract from a Russian group that claims a peptide can turn on

1: Bull Exp Biol Med. 2003 Jun;135(6):590-2.    <A
pt=pubmed_pubmed&from_uid=12937682">Related Articles,</A> >Links</A>

Epithalon Peptide induces telomerase activity and telomere elongation in
human somatic cells.

Khavinson VKh, Bondarev IE, Butyugov AA.

St. Petersburg Institute of Bioregulation and Gerontology, North-Western
Division of Russian Academy of Medical Sciences.

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