X-Message-Number: 24586
Date: Fri, 3 Sep 2004 05:18:38 -0700 (PDT)
From: Doug Skrecky <>
Subject: contradictory effects of resveratrol on lifespan

[My own fly longevity experiments have had consistently negative results
with resveratrol and other STACs. The following experiment may explain
why this is so.]

 Nature. 2004 Aug 5;430(7000):686-9. Epub 2004 Jul 14.
Sirtuin activators mimic caloric restriction and delay ageing in metazoans.
  Caloric restriction extends lifespan in numerous species. In the budding
yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a
member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin
activating compounds (STACs) can promote the survival of human cells and
extend the replicative lifespan of yeast. Here we show that resveratrol
and other STACs activate sirtuins from Caenorhabditis elegans and
Drosophila melanogaster, and extend the lifespan of these animals without
reducing fecundity. Lifespan extension is dependent on functional Sir2,
and is not observed when nutrients are restricted. Together these data
indicate that STACs slow metazoan ageing by mechanisms that may be
related to caloric restriction.

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