X-Message-Number: 24593
Date: Sun, 5 Sep 2004 13:55:27 -0700 (PDT)
From: Doug Skrecky <>
Subject: resveratrol and fly aging

> Message #24590 Thomas Donaldson <> wrote:
>
> I have already discussed the problems with inferring lifespan-extending
> therapies from their effects on fruit flies. However I don't quite
> understand how your reference in NATURE explains why your own
> experiments with resveratrol didn't show any lifespan increse. Were
> you restricting the diets of these fruit flies at the same time
> as you gave them resveratrol?
>
  I was hoping to save this sort of talk, till after some critical
experiments were completed. However for now, I will just mention that
most longevity fly experiments, whether done by myself, or by publishing
scientists are conducted at the lower end of the "calorie curve", as it
were. This is to say that while increases in calorie intake can reduce fly
longevity significantly, decreases exert little or no benefit. Since
resveratrol and other STACS are now believed to act as caloric
restriction mimetics, via homologous actions on sirtuins, it follows that
these mimetics can be expected to offer little or no benefit in most fly
experiments.
 I hope to have more to say about this in future, as well as about
differences between aging flys, rodents, and humans. All of these are
affected quite differently by diverse aging related (and nonrelated)
processes.

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