X-Message-Number: 25875
Date: Wed, 23 Mar 2005 20:16:51 -0800 (PST)
From: Doug Skrecky <>
Subject: life extension spices?

Ann N Y Acad Sci. 2004 Dec;1030:434-41.
Suppression of the Nuclear Factor-{kappa}B Activation Pathway by
Spice-Derived Phytochemicals: Reasoning for Seasoning.
    The activation of nuclear transcription factor kappaB has now
been linked with a variety of inflammatory diseases, including
cancer, atherosclerosis, myocardial infarction, diabetes, allergy,
asthma, arthritis, Crohn's disease, multiple sclerosis,
Alzheimer's disease, osteoporosis, psoriasis, septic shock, and
AIDS. Extensive research in the last few years has shown that
the pathway that activates this transcription factor can be
interrupted by phytochemicals derived from spices such as turmeric
(curcumin), red pepper (capsaicin), cloves (eugenol), ginger
(gingerol), cumin, anise, and fennel (anethol), basil and rosemary
(ursolic acid), garlic (diallyl sulfide, S-allylmercaptocysteine,
ajoene), and pomegranate (ellagic acid). For the first time,
therefore, research provides "reasoning for seasoning."

Biochem Cell Biol. 2005 Feb;83(1):78-85
Rose (Rosa rugosa)-flower extract increases the activities of
antioxidant enzymes and their gene expression and reduces lipid
peroxidation.
    The effects of rose-flower extract on antioxidant enzymes were
studied. The activities of catalase (CAT) and glutathione
peroxidase (GPx) in 9-month-old senescence-accelerated mice
(SAM mice) were lower than those in 6-month-old SAM mice.
Therefore, 9-month-old SAM mice were the most appropriate targets
for treatment with the rose-flower extract. The activities of CAT
and GPx in SAM mice treated with rose-flower extract showed a
marked increase in whole blood and liver. At the same time, the
gene-expression level of CAT and GPx was upregulated in the liver,
while malondialdehyde content in liver and brain decreased. Male
SAM mice were more sensitive than female SAM mice. The mean and
the longest lifespan of SAM mice were longer after treatment with
rose-flower extract.Key word: anti-aging, CAT, GPx, lipid
peroxidation.

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