X-Message-Number: 25897
Date: Sun, 27 Mar 2005 14:16:23 -0800 (PST)
From: Doug Skrecky <>
Subject: 170'th update on fly longevity experiments

     This is the 170'th update of my fly longevity experiments. Average
 temperature was 21.2 C during this run. Estimated maximal longevity using
 the formula (363 - T*11.2) is 126 days.
     In this run I tested Foo-Ti-Teng and Remember-FX because some claims
 had  been made that these might help protect nerve cells from
 degeneration. Remember-FX contains a patented extract from panax
 quinquefolium, and Foo-Ti-Teng contained a polygonum multiforum powder.
     Remember-FX proved to be dud, but the cheaper Foo-Ti-Teng did appear
 to offer some neurological support, with some flying ability remaining
 intact at the 96 day census in both bottles, as well as a modestly
 increased maximum lifespan relative to the other bottles.
     I'd tried and failed on numerous occasions to obtain any longevity
 benefit from sources of resveratrol. This putative calorie restriction
 mimetic had been claimed to activate sirtuins just as CR does. However
 recently this sirtuin activating effect of resveratrol has been refuted,
 with no effect being obtained with pure resveratrol. One possible
 explanation for the conflicting results with resveratrol may be that it
 is admixtures of other stilbene glucosides that are the real sirtuin
 activators. The main antioxidant in Foo-Ti-Teng just happens to be a
 tetrahydroxystilbene glucoside, and I'm now wondering whether this is a
 sirtuin activator, and if this supplement might serve as an effective
 calorie restriction mimetic. Of course, I'll be retesting [Albi]
 Foo-Ti-Teng on fly longevity.

 Run #170                       Percent Survival on Day
 supplement          16 26 36 46 54 63 77 84 96 106 109 115 122 127
 __________________________________________________________________
 control one         83 75 67 63 50 42 21  7  4   4   0   -   -   -
 control two         87 78 70 65 57 44 17  9  0   -   -   -   -   -
 Foo-Ti-Teng 130 mg  86 67 43 43 43 33 29 19 10  10  10   5   5   0
    "        518 mg  79 54 46 42 38 29 21 21  8   4   4   0   -   -
 kapurkachi 1/8 tsp  96 78 78 70 61 39 13  4  0   -   -   -   -   -
    "       1/2 tsp  70 60 60 60 45 25  5  0  -   -   -   -   -   -
 onion skin 1/8 tsp  81 62 52 38 14 14  5  0  -   -   -   -   -   -
    "       1/2 tsp  73 64 55 55 46 41 23  5  0   -   -   -   -   -
 Remember-FX 25 mg   82 70 63 59 44 33 15  7  4   0   -   -   -   -
    "       100 mg   76 68 56 48 40 36 16  8  4   0   -   -   -   -

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