X-Message-Number: 26375
References: <>
From: Kennita Watson <>
Subject: Re: CryoNet #26365 - #26369
Date: Wed, 22 Jun 2005 14:21:21 -0700

Doug Skrecky wrote:

>     Cerium oxide nanoparticles turned out to be non-toxic to flies at 
> all
>  concentrations. However no effect on fly longevity was observed. I 
> have
>  to regard this as a refutation of the free radical theory of aging.
>     Playing the devil's advocate, this test of the free radical theory 
> of
>  aging could be criticized along the following lines. The particle size
>  may have been too large so mitochondrial penetration may have been as
>  issue. Possibly too high a concentration of nanoparticles was used.
>
Also, the cells tested in vitro were brain cells.
Maybe the fly food nanoparticles couldn't make it
across the blood-brain barrier -- and might not
in live rats, either.

Kennita

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