X-Message-Number: 26536
From: David Stodolsky <>
Subject: Complex Dietary Supplement Extends Longevity of Mice
Date: Wed, 6 Jul 2005 22:45:10 +0200

  The Journals of Gerontology Series A: Biological Sciences and Medical 
Sciences 60:275-279 (2005)
  2005 The Gerontological Society of America
A Complex Dietary Supplement Extends Longevity of Mice

Jennifer A. Lemon1,, Douglas R. Boreham2 and C. David Rollo1
1 Departments of Biology
2 Medical Physics and Applied Radiation Sciences, McMaster University, 
Hamilton, Ontario, Canada.

Correspondence: Address correspondence to Jennifer Lemon, Department of 
Biology, McMaster University, 1280 Main Street West, Hamilton, ON, 
Canada L8S 4K1. E-mail: 

Key factors implicated in aging include reactive oxygen species, 
inflammatory processes, insulin resistance, and mitochondrial 
dysfunction. All are exaggerated in transgenic growth hormone mice 
(TGM), which display a syndrome resembling accelerated aging. We 
formulated a complex dietary supplement containing 31 ingredients known 
to ameliorate all of the above features. We previously showed that this 
supplement completely abolished the severe age-related cognitive 
decline expressed by untreated TGM. Here we report that longevity of 
both TGM and normal mice is extended by this supplement. Treated TGM 
showed a 28% increase (p <.00008) in mean longevity. An 11% increase in 
mean longevity was also significant (p <.002093) for treated normal 
mice, compared to untreated normal mice. These data support the 
hypothesis that TGM are a model of accelerated aging, and demonstrate 
that complex dietary supplements may be effective in ameliorating aging 
or age-related pathologies where simpler formulations have generally 
failed.



David S. Stodolsky    SpamTo: 

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