X-Message-Number: 26740
From: 
Subject: Brain Vitrification
Date: Sat, 30 Jul 2005 22:01:40 +0000

--NextPart_Webmail_9m3u9jl4l_12276_1122760900_0

     In Cryomsg 26716, Robert Ettinger wrote:


> As far as I know, nobody--nobody, nobody, nobody--has yet vitrified a whole 
mammalian brain and quantified the results in various segments and subsegments.

In Cryomsg 26723, Joe Waynick replied


> Mr. Ettinger makes an important point when he says  nobody--has yet vitrified 
a whole mammalian brain and quantified the results in various segments and 
subsegments.  I think that is an important and necessary bit of work and I want 
our membership to know that Alcor is currently considering those issues as a 
research project.


      These statements are mistaken.  Shortly before Joe Waynick became Alcor's 
      new CEO, Alcor in fact presented the results of a whole mammalian brain 
      vitrification study with detailed electron microscopy results in multiple 
      brain regions at the 10th Congress of The International Association of 
      Biomedical Gerontology at Queen's College, Cambridge, England. 

http://www.alcor.org/Library/html/cambridge.html


Last year this work appeared in a paper in the journal Annals of the New York 
Academy of Sciences

http://www.alcor.org/Library/html/annals.html


These results have since been replicated by cooling brains at human cryopatient 
core cooling rates to below the glass transition temperature (vitrification) and
back again without signs of ice formation on electron micrographs.  The results
are further confirmed as credible by the presentation of data at this years 
Society for Cryobiology meeting showing that the vitrification solution used, 
M22, can be vitrified in large volumes cooling at only 0.1 degC per minute 
without ice formation.


     Whole mammalian brains can and have been structurally vitrified, even at 
     very slow cooling rates.

----Brian Wowk
--NextPart_Webmail_9m3u9jl4l_12276_1122760900_0

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