X-Message-Number: 27082
Date: Mon, 19 Sep 2005 11:36:27 -0700 (PDT)
From: Doug Skrecky <>
Subject: 195'th update on fly longevity experiments
This is the 195'th update of my fly longevity experiments. Average
temperature was 26.3 C during this run. Estimated maximal longevity using
the formula (363 - T*11.2) is 68 days.
Ashwaganda has stimulated repair processes in mammals. Although
drosophila cells are virtually all post-mitotic, ashwaganda is a good
test case to see if repair processes are likely to be relevant to fly
aging. Unfortunately, the negative results in this run indicate that the
answer to this question is probably "no".
A number of supplements for which "hits" were obtained in previous
runs are also here retested. In run #191 the antidiabetic supplement
gymnema sylvestre was associated with improved mean, but not maximum
survival at a 200 mg dosage. In run #178 the neuroprotective supplement
bacopa monniera was also associated with increased mean. but not maximum
survival at a 75 mg dosage. In run #177 the radioprotective supplement
triphala increased maximum, but not mean survival at a 250 mg dosage. In
run #170 the neuroprotective supplement foo-ti-teng increased maximum,
but not mean survival at a 130 mg dosage. None of these "effects" are
statistically robust, so this run is really giving all of these
supplements an opportunity to win a place on my own list of fly longevity
enhancing supplements. Alas, none of these made the grade this time.
Run #195 Percent Survival on Day
supplement 12 22 32 39 46 51 58
______________________________________________
control one 73 67 46 36 9 0 -
control two 77 65 62 58 31 12 0
ashwaganda 1/16 tsp 67 54 50 38 17 0 -
" 1/8 tsp 56 50 38 25 13 3 0
" 1/4 tsp 62 62 50 35 12 0 -
" 1/2 tsp 62 50 39 19 4 0 -
" 1 tsp 71 52 38 24 5 0 -
bacopa monniera 38 mg 39 35 30 22 0 - -
" 75 mg 68 64 59 55 27 0 -
foo-ti-teng 65 mg 53 42 42 21 11 0 -
" 130 mg 74 66 51 46 37 0 -
gymnema sylvestre 200 mg 44 30 30 22 0 - -
" 400 mg 54 42 38 29 0 - -
muira puama 19 mg 61 57 39 17 9 0 -
" 75 mg 64 44 28 24 12 0 -
" 300 mg 50 45 25 20 10 0 -
triphala 250 mg 55 42 19 19 10 3 0
" 500 mg 44 40 36 24 8 0 -
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