X-Message-Number: 27826
Date: Sat, 8 Apr 2006 19:02:45 -0700 (PDT)
From: Doug Skrecky <>
Subject: MLH1 and longevity

Hum Genet. 2006 Apr;119(3):353-4. Epub 2006 Feb 11.
Association between the MLH1 gene and longevity.
  Perturbations in genomic stability result in cancer, a reduced life
span, and premature aging. MLH1 is a mismatch repair enzyme that acts to
maintain genomic stability, and a loss of MLH1 increases cancer incidence
and apoptosis resistance, which suggests a link between MLH1 and
longevity. We found here that MLH1 is associated with longevity by
comparing a centenarian group with a control group. Our data indicate a
critical role for MLH1 in longevity.

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