X-Message-Number: 29680
Date: Fri, 27 Jul 2007 00:30:13 -0700 (PDT)
From: 
Subject: Long lived and fat

Science. 2007 Jul 20;317(5836):369-72.
Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis.
    Taguchi A, Wartschow LM, White MF. Howard Hughes Medical Institute,
Division of Endocrinology, Children's Hospital Boston, Harvard Medical
School, Boston, MA 02115, USA.
    Reduced insulin-like signaling extends the life span of
Caenorhabditis elegans and Drosophila. Here, we show that, in mice, less
insulin receptor substrate-2 (Irs2) signaling throughout the body or just
in the brain extended life span up to 18%. At 22 months of age,
brain-specific Irs2 knockout mice were overweight, hyperinsulinemic, and
glucose intolerant; however, compared with control mice, they were more
active and displayed greater glucose oxidation, and during meals they
displayed stable superoxide dismutase-2 concentrations in the
hypothalamus. Thus, less Irs2 signaling in aging brains can promote
healthy metabolism, attenuate meal-induced oxidative stress, and extend
the life span of overweight and insulin-resistant mice.
PMID: 17641201

Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=29680