X-Message-Number: 30110
Subject: RE: [CN] December 2007 issue, on the stands now
Date: Fri, 7 Dec 2007 10:45:25 -0500
References: <>
From: "Hare, Tim R" <>

On 12/7/2007 David Stodolsky wrote:

>>On 6 Dec 2007, at 01:07, Chris Manning wrote:
>>
>> - I took up drinking red wine a few months ago. I have heard/read  
>> so many
>> people claim health benefits for moderate consumption of red wine  
>> that I
>> think it must be true.
>
This isn't a valid basis, as anyone following the WMD debate up to  
the Iraq War knows.

One glass a day is the limit and that is only justified if you suffer  
from low HDL cholesterol. A women should take a folic acid supplement  
to avoid an increased risk of cancer. See Willett 2001 for details.

------
TRH: 2001?  More recent references below suggest you'll have women
promoting carcinogenesis via ETOH-derived frank carcinogens, and
supporting selection for neoplastic the phenotype with
hyper-methylation.  Net-net?  Fostering cancer through mutation and
selection.  I've said this before, and I'll say it again: Cite your own
authority less, and an unbiased sampling of the other information more
('the Literature', if you prefer), to best inform the group.  Also,
comments like "This isn't a valid basis, as anyone following the WMD
debate up to the Iraq War knows." is simply provocative; why not gently
suggest that following the crowd has it's drawbacks?

"In both HCT116 and Caco2 cells, folate depletion was associated with
the conservation of the existing pattern and extent of DNA methylation."
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&Te
rmToSearch=17311948&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubm
ed_ResultsPanel.Pubmed_RVAbstractPlus

"These results are in agreement with the promoting effect of folic acid
supplementation on established colorectal neoplasms." 
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&Te
rmToSearch=17868486&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubm
ed_ResultsPanel.Pubmed_RVDocSum


"In contrast to the cancer-promoting effect of folate deficiency in
normal tissues, several lines of evidence indicate that folate depletion
suppresses the progression of existing neoplasms and enhance the
sensitivity of cancer cells to chemotherapy."

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&Te
rmToSearch=16361273&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubm
ed_ResultsPanel.Pubmed_RVAbstractPlus

"Acetaldehyde (AA) is the major metabolite of ethanol and may be
responsible for an increased gastrointestinal cancer risk associated
with alcohol beverage consumption. Furthermore, AA is one of the most
abundant carcinogens in tobacco smoke and induces tumors of the
respiratory tract in laboratory animals."
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&Te
rmToSearch=17867647&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubm
ed_ResultsPanel.Pubmed_RVDocSum

TRH
-------

dss


David Stodolsky    Skype: davidstodolsky

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