X-Message-Number: 5354
From:  (Brian Wowk)
Newsgroups: sci.cryonics
Subject: Re: High Pressure Cryonics
Date: 5 Dec 95 20:47:27 GMT
Message-ID: <>
References: <> <4a0mf5$>

In <4a0mf5$>  (JensTroll) writes:

JT>I question how "pure hydrostactic pressure" using a liquid  even at levals
JT>as high as 2-3000 barr could cause damage to tissues.  

JT>I suspect that the damage was caused by 1) too rapid application or
JT>release of pressure, 2) too high partial pressures of reactive gasses
JT>disolved in the liquid (especially oxygen), 3) too high partal pressures
JT>of any gasses combined with a too  rapid release of pressure could cause a
JT>lot of damage.  Has this research addressed these issues????

	Unfortunately my limited knowledge on this subject is second
hand.  Still, why do you reject protein denaturation as a damage  
mechanism?  Obviously the nature of hydrogen bonds changes with
hydrostatic pressure, or you wouldn't get all those bizarre types  
of ice forming in the first place.  If you alter hydrogen bonding
in water with pressure, you sure as heck will alter the hydrogen
bonding that determines the conformation of proteins. 

---Brian Wowk    	 


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