X-Message-Number: 8424 Date: Mon, 28 Jul 1997 13:37:03 -0400 From: yvan Bozzonetti <> Subject: Hot cryonics After my my message #8417, Douglas Skrecky said in # 8418: >As far as I >am aware all potential cryoprotectants that could be used in conjunction >with dry ice storage suffer from relatively slow permeation into tissue. >So preparation of tissue with sorbitol and other "solid" cryoprotectants >would be time consuming relative to current procedures, which use >glycerol. Often different properties of a molecule come from different parts of that molecule. So, there is some hope to graft a cryoprotective part on a high permeability part to get a good product. This is quantum chemistry design, a very specialised activity and somewhat costly. It may not be the best investment at the time. Neverthless D. Skecky continues: > One cryoprotectant that shows promise here is adonitol, which >permeates cell membranes over 30 times as quickly as sorbitol >yet still melts at a warm and toasty 102 C. For those concerned about >safety or expense of cryonic storage, adonitol might be close to being the >optimal choice of cryoprotectant for use in conjunction with dry ice >storage. This is very interesting: May we have the solution at hand without costly molecular design? I have the possibility to work at dry ice temperature. If someone can suggest a source for adonitol it could be interesting to see how it behave. Yvan Bozzonetti. Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=8424