X-Message-Number: 8424
Date: Mon, 28 Jul 1997 13:37:03 -0400
From: yvan Bozzonetti <>
Subject: Hot cryonics

After my my message #8417, Douglas Skrecky said in # 8418:

>As far as I
>am aware all potential cryoprotectants that could be used in conjunction
>with dry ice storage suffer from relatively slow permeation into tissue.
>So preparation of tissue with sorbitol and other "solid" cryoprotectants
>would be time consuming relative to current procedures, which use
>glycerol.

        Often different properties of a molecule come from different parts
of that molecule. So, there is some hope to graft a cryoprotective part on
a high permeability part to get a good product. This is quantum chemistry
design, a very specialised activity and somewhat costly. It may not be the
best investment at the time. Neverthless D. Skecky continues:

>  One cryoprotectant that shows promise here is adonitol, which
>permeates cell membranes over 30 times as quickly as sorbitol 
>yet still melts at a warm and toasty 102 C. For those concerned about
>safety or expense of cryonic storage, adonitol might be close to being the
>optimal choice of cryoprotectant for use in conjunction with dry ice
>storage.

This is very interesting: May we have the solution at hand without costly
molecular design? I have the possibility to work at dry ice temperature. If
someone can suggest a source for adonitol it could be interesting to see
how it behave.

Yvan Bozzonetti.

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