X-Message-Number: 9968 Date: Thu, 2 Jul 1998 20:41:07 -0700 (PDT) From: Doug Skrecky <> Subject: food restriction, deprenyl, nimodipine & the SHRSP rat Neurobiology of Aging 19(3): 273-276 1998 "Long-Term Food Restriction, Deprenyl, and Nimodipine Treatment on Life Expectancy and Blood Pressure of Stroke-Prone Rats" Abstract: We determined whether food restriction or the drugs nimodipine (Ca2+ antagonist) and deprenyl (a MAO-B inhibitor) prevent the development of stroke in the spontaneously hypertensive stroke-prone rat (SHR-SP). Forty male SHR-SP rats, in the age of 34 weeks, were exposed to various treatments. During a period of 27 weeks, survival and blood pressure were followed. In the control and deprenyl group, the blood pressure values remianed unchanged; 50% had died after 27 weeks. All rats that were treated with nimodipine survived. After food restriction, 7/8 rats survived and showed a lower blood pressure. This study in SHR-SP rats shows the superiority of nimodipine on survival, and the potential of food restriction as a stroke-preventing measure. Rate This Message: http://www.cryonet.org/cgi-bin/rate.cgi?msg=9968